Holobiomics Lab.

Adults spend most of their time indoors, yet indoor air quality, the indoor microbiome, and human physiology are usually studied in isolation. Holobiomics Lab brings them together through the concept of the human holobiont: a person and their microbes as one interacting system. The project combines continuous bedroom air monitoring, profiling of house dust, nasal, and gut microbiomes, wearable measures of autonomic function and sleep, daily dietary records, and outdoor exposure in a longitudinal intervention study. It tests whether poor ventilation affects autonomic regulation, whether indoor and human microbiomes share core taxa, and whether simple behavioral changes, such as structured ventilation and more time outdoors, shift both. Interpretable machine learning and compositional statistics will integrate these data streams to identify modifiable pathways between the built environment and health. Protocols, data, and code will be shared openly following FAIR principles. The project also establishes a dedicated holobiomics research group at the Institute for Anthropological Research.